… inhibition of bromodomain-containing protein 4 (Brd4) in UUO, a protein that upregulates the
transcriptional activity of NOX4… , SOD 1, and 2 expressions, with attenuation of H 2 O 2 and …

… First, we investigated whether Brd4 regulates Nox4 gene expression. Primary IPF lung …
We demonstrate that Brd4 inhibition partially blocks p300 recruitment/stabilization, and its …

… lung fibrosis through transcriptional elongation [13]. Also, BRD4 inhibition attenuates
cardiomyocyte … BRD4 modulated Nox4 expression to block TGF-β1-induced oxidative stress and …

… pharmacological inhibition of PAR-1 by vorapaxar attenuated … Expression of Nox4 is up-regulated
in UUO-induced fibrotic … its inhibition by vorapaxar inhibited TGF-β-mediated ECM …

… can attenuate renal injury and fibrosis in the UUO model. … fibrosis in the UUO model [67,68].
In this study, we observed that CS treatment reduced NOX4 mRNA and protein expression in …

… NOX4 expression by carnosic acid treatment has been proved to protect against unilateral
ureteral obstruction-induced renal fibrosis… [60] could attenuate the progression of fibrogenesis. …

… Inhibition of BRD4 attenuated renal fibrosis by blocking TGF-β-mediated Nox4 expression
[… Another study showed that suppression of BRD4 by JQ1 robustly blocked TGFBR2 level in …

… in CF and that BRD4 inhibitors can block the EndMT process… sh-BRD4 mimicked the effects
of JQ1 on the TGF-β-mediated … , we used BRD4 inhibitor JQ1 to examine the expression of …

… the Nox4 promoter in a BRD4-dependent manner and increasing … by which BRD4 inhibition
blocks TGF-β-mediated EndMT is by … In addition to attenuating EndMT, BRD4 inhibition also …

… microalbumin, and attenuated renal fibrosis as indicated by … , we examined the expression
of Brd2, Brd3 and Brd4 in the … to block NF-κB activation via disrupting the interaction of Brd4 …